To be able to use SSL for Pyramid website it should be installed using the IIS option.
Once installed add an SSL bindings as shown below:

1. Right Click on the "Pyramid" site and choose edit bindings(1)>Click on Add(2)>Choose "https"(3)>set the required 
   host name(4) > Choose your SSL certificate(5)
    
2. Edit the web.config of the site, which by default is: C:\program files\pyramid\repository\iis\web.config
   
   Add the following lines (in Bold text):
   By adding these lines in the web.config, all HTTP requests will be redirected to HTTPS.

<?xml version="1.0" encoding="UTF-8"?>
<configuration>
  <system.webServer>
    <rewrite>
      <rules>
        <rule name="HTTP/S to HTTPS Redirect" enabled="true" stopProcessing="true">
          <match url="(.*)" />
          <conditions logicalGrouping="MatchAny">
            <add input="{SERVER_PORT_SECURE}" pattern="^0$" />
          </conditions>
          <action type="Redirect" url="https://{HTTP_HOST}{REQUEST_URI}" redirectType="Permanent" />
        </rule>
        <rule name="ReverseProxyInboundRule1" stopProcessing="true">
          <match url="(.*)" />
          <action type="Rewrite" url="http://localhost:8181/{R:1}" />
        </rule>
      </rules>
    </rewrite>
    <defaultDocument>
      <files>
        <clear />
        <add value="readme.html" />
      </files>
    </defaultDocument>
  </system.webServer>
 </configuration>